Unleashing Potential of Bone Mimicking

Nanodimensional Hydroxyapatites

and Their Biomedical Applications

23

Seema Kapoor, Uma Batra, and Suchita Kohli

Abstract

Ionic substitution in nanodimensional hydroxyapatite (HA) offers numerous

advantages including control of physicochemical properties, strong host

interactions, biocompatibility, bioactivity, osteoconductivity, etc. In this chapter,

the facile route of synthesis of novel hydroxyapatites, strategies to substitute ions,

heat treatment of nanopowders, structural stability and thermal stability, in vitro

biomineralization, and coating applications have been discussed. Nanotechnol-

ogy, ionic substitution, and heat treatment have shown improvement in physico-

chemical characteristics of novel hydroxyapatites, which offer potential in a wide

range of biomedical applications.

Keywords

Hydroxyapatite · Nanodimensional · Ionic substitution · Heat treatment · Coatings

23.1

Introduction

Hydroxyapatite (HA) is considered as a mineralized bone-like phase, and its poten-

tial for bone regeneration orthopedic surgeries has been well recognized. Despite the

undeniable biocompatibility of HA, the overall prospect of hydroxyapatite for

S. Kapoor (*) · S. Kohli

Dr. S.S.B. University Institute of Chemical Engineering and Technology, Panjab University,

Chandigarh, India

e-mail: seemakapoor@pu.ac.in; seemakap2014@gmail.com

U. Batra

Department of Materials and Metallurgical Engineering, PEC (Deemed to be University),

Chandigarh, India

# The Author(s), under exclusive license to Springer Nature Singapore Pte

Ltd. 2022

R. C. Sobti, N. S. Dhalla (eds.), Biomedical Translational Research,

https://doi.org/10.1007/978-981-16-9232-1_23

419